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Comparing the short-term efficacy of rofecoxib versus placebo. Patients receive rofecoxib or placebo or diclofenac and fill out a patient diary on daytime pain severity during daily activities, night pain severity, and acetaminophen/paracetamol intake.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0966; rofecoxib | Drug | |||
| Comparator: diclofenac, placebo | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Pain during daily activities assessed by a Numerical Rating Score (NRS) |
| Measure | Description | Time Frame |
|---|---|---|
| Functional impairment evaluated using Neer's functional index. | ||
| Global assessment of disease activity by the patient with a NRS. | ||
| Intensity of night pain evaluated by NRS. |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratoires Merck Sharp & Dohme - Chibret | Paris | 75114 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32797734 | Derived | Jones P, Lamdin R, Dalziel SR. Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. Cochrane Database Syst Rev. 2020 Aug 12;8(8):CD007789. doi: 10.1002/14651858.CD007789.pub3. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C116926 | rofecoxib |
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| Rescue treatment take during the study duration. |