Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients

Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction

In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.

Inclusion Criteria:

• Age between 18 and 60 yrs.
• Verified hypopituitarism
• Unchanged substitution treatment through 3+ months
• Unchanged additional medical treatment
• Oral and written informed consent

Exclusion Criteria:

• Age below 18 or above 60 yrs.
• Diabetes mellitus
• body mass index > 30
• Fasting hypoglycemia
• Convulsions
• Allergy to trial products