Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis. A Randomized Double-blind Comparison

The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.

Inclusion Criteria:

• Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:

  • Intrathecal production of borrelia antibodies;
  • White cell count in cerebrospinal fluid (CSF) > 5/mm3;
  • Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;
  • Verified acrodermatitis chronica atrophicans.

Exclusion Criteria:

• Allergy to the contents in the medication, or earlier type I reaction to penicillin.
• Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days
• Pregnancy or breastfeeding
• Age < 18 years