Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Three protocols are used to treat ectopic pregnancies: medical treatment by methotrexate, conservative surgery or radical surgery. There are no data about subsequent fertility except in a cohort study. The investigators propose to evaluate the true subsequent fertility with a follow-up of 2 years, in a randomized controlled trial.
The first group includes non active ectopic pregnancies defined by score or algorithm. In this case, we propose a randomized controlled trial between medical and conservative surgery. In all others clinical situations, we proposed surgery treatment. In a randomized controlled trial we compare conservative versus radical treatment. The patients are followed-up during 2 years with phone contact every 6 months.
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Treatment of ectopic pregnancy | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Subsequent fertility with 2 years follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Complications of treatments | ||
| Time of hospitalisation | ||
| Decrease curve of beta-hCG after treatment |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fernandez Hervé, PhD MD | Contact | +33 1 45 37 44 69 | herve.fernandez@abc.aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Fernandez Hervé, PhD MD | Hopital Antoine Beclere | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Angers Hospital | Recruiting | Angers | 49033 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15388673 | Background | Fernandez H, Gervaise A. Ectopic pregnancies after infertility treatment: modern diagnosis and therapeutic strategy. Hum Reprod Update. 2004 Nov-Dec;10(6):503-13. doi: 10.1093/humupd/dmh043. Epub 2004 Sep 23. | |
| 30520964 | Derived | Bourel G, Pelletier-Fleury N, Bouyer J, Delbarre A, Fernandez H, Capmas P. Cost-effectiveness analysis of medical management versus conservative surgery for early tubal pregnancy. Hum Reprod. 2019 Feb 1;34(2):261-267. doi: 10.1093/humrep/dey352. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Success rate in each group |
| Antoine Beclere Hospital | Recruiting | Clamart | 92140 | France |
|
| Créteil Hospital | Recruiting | Créteil | 94000 | France |
|
| Franco-Britannique Hospital | Recruiting | Levallois-Perret | 92300 | France |
|
| Jeanne de Flandre Hospital | Recruiting | Lille | 59037 | France |
|
| Hôtel Dieu | Recruiting | Lyon | 69288 | France |
|
| Assistance Publique Hôpitaux de Marseille ; Maternité de la Conception | Recruiting | Marseille | 13005 | France |
|
| Assistance Publique Hôpitaux de Marseille ; Hôpital Nord | Recruiting | Marseille | 13326 | France |
|
| Maternité Régionale de Nancy | Recruiting | Nancy | 54042 | France |
|
| Nantes Hospital | Recruiting | Nantes | 44093 | France |
|
| Lariboisière Hospital | Recruiting | Paris | 75010 | France |
|
| Cochin Hospital | Recruiting | Paris | 75679 | France |
|
| Poissy Saint-Germain-en-Laye Hospital | Recruiting | Poissy | 78303 | France |
|
| Roubaix Hospital | Recruiting | Roubaix | 59100 | France |
|
| Charles Nicolle Hospital | Recruiting | Rouen | 76031 | France |
|
| CMCO | Recruiting | Schiltigheim | 67303 | France |
|
| Tours Hospital | Not yet recruiting | Tours | 37000 | France |
|
| Versailles Hospital ; Hôpital André Mignot | Recruiting | Versailles | 78157 | France |
|
| 23482340 | Derived | Fernandez H, Capmas P, Lucot JP, Resch B, Panel P, Bouyer J; GROG. Fertility after ectopic pregnancy: the DEMETER randomized trial. Hum Reprod. 2013 May;28(5):1247-53. doi: 10.1093/humrep/det037. Epub 2013 Mar 12. |
| ID | Term |
|---|---|
| D011274 | Pregnancy, Tubal |
| D011271 | Pregnancy, Ectopic |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
Not provided
Not provided