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The investigators aimed to investigate the effects of salpingectomy and Methotrexate administration on ovarian reserve in ectopic pregnancy.
In this study, the effects of unilateral laparoscopic salpingectomy and single dose of systemic Methotrexate administration on ovarian reserve in patients diagnosed with ectopic pregnancy were investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Methotrexate only | Active Comparator | Single dose of systemic Methotrexate administered to 55 patients. |
|
| Salpingectomy only group | Active Comparator | Laparoscopic unilateral salpingectomy performed to 61 patients. |
|
| Salpingectomy following Methotrexate | Active Comparator | 15 patients underwent laparoscopic unilateral salpingectomy following unsuccessful single dose of methotrexate administration. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methotrexate | Drug | single dose systemic methotrexate administration (50 mg/m2) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ovarian reserve assessment by measuring AMH level. | Ovarian reserve were assessed before and after treatment by measuring AMH levels. | 1-3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with treatment related adverse effect on fertility. | Rates of term delivery, spontaneous abortion, recurrent ectopic pregnancy and ongoing pregnancy for each group of patients were calculated during 2 years of follow up period. | 2 years of follow up after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ahmet M. Ergenoglu, Ass. Prof. | Ege University School of Medicine Department of Obstetrics and Gynecology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ege University School of Medicine Department of Obstetrics and Gynecology | Izmir | 35100 | Turkey (Türkiye) |
The investigators have not decided to share patient data yet. However, it is possible if approved by ethical committee.
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| ID | Term |
|---|---|
| D011271 | Pregnancy, Ectopic |
| D007246 | Infertility |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
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| ID | Term |
|---|---|
| D008727 | Methotrexate |
| D058994 | Salpingectomy |
| ID | Term |
|---|---|
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| salpingectomy | Procedure | Laparoscopic unilateral salpingectomy |
|
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D013509 | Gynecologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |
| D013514 | Surgical Procedures, Operative |