A 39 Week Randomized, Double-Blind, Parallel Group, Multicenter Study to Evaluate the Effect of Fixed Dose Carbidopa/Levodopa/Entacapone 100 mg t.i.d. vs. Immediate Release Carbidopa/Levodopa 25/100 mg (t.i.d.) in Parkinson's Disease Patients Requiring Levodopa
A 39 Week Randomized, Double-Blind, Parallel Group, Multicenter Study to Evaluate the Effect of Fixed Dose Carbidopa/Levodopa/Entacapone 100 mg t.i.d. vs. Immediate Release Carbidopa/Levodopa 25/100 mg (t.i.d.) in Parkinson's Disease Patients Requiring Levodopa
The purpose of this study is to achieve approval for the use of carbidopa/levodopa/entacapone in early Parkinson's disease (PD) by demonstrating that when used as initial levodopa therapy in early PD, carbidopa/levodopa/entacapone provides significantly greater symptomatic benefit than immediate release carbidopa/levodopa administered at the same levodopa dosage level of 100 mg three times a day (t.i.d.).
The purpose of this study is to achieve approval for the use of carbidopa/levodopa/entacapone in early Parkinson's disease (PD) by demonstrating that when used as initial levodopa therapy in early PD, carbidopa/levodopa/entacapone provides significantly greater symptomatic benefit than immediate release carbidopa/levodopa administered at the same levodopa dosage level 100 mg t.i.d.
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Exclusion Criteria:
Phoenix, Arizona 85013, United States
HSC Room 5317, 300 Prince Philip Drive, Saint John's, Newfoundland and Labrador A1B 3V6, Canada
I.P.Pavlova 6, Olomouc 775 20, Czechia
Alej Svobody 80, Plzeň 304 60, Czechia
Haliya Hashniya 8, Haifa District 31096, Israel
Via Santa Sofia 78, Catania 95123, Italy
Università Degli Studi Di Genova, Via de Toni 5, Genova 16132, Italy
Via Consolare Valeria, Messina 98125, Italy
Via Celoria 11, Milano 20100, Italy
Via Roma, 67, Pisa 56127, Italy
Viale dell'Università 30, Roma 00185, Italy
Via Cherasco 15, Torino 10126, Italy
Via Bignami 1, Milan, 20126, Italy
Ul. Czerniakowska 231, Warszawa, 00-416, Poland
Avenida Bissaya Barreto, Coimbra, 3000-075, Portugal
Istanbul University CAPA Medical School, Dept. of Neurology, Istanbul 34610, Turkey (Türkiye)
Hacettepe Universitesi Hastaneleri Norooji AD Sihhiye, Ankara, 6,100, Turkey (Türkiye)