Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia

Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial)

A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.

This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls.

Inclusion Criteria:

• Primiparous
• History of preeclampsia
• Low plasma volume

Exclusion Criteria:

• Thrombophilia
• Hypertension
• Auto-immune disorder
• Insulin dependent diabetes mellitus