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Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF). Laser-assisted ICSI differs from conventional ICSI in that a laser is used to drill a small hole through the hard outer coating surrounding an egg before the injection needle containing a single sperm is inserted into the egg. The hole eliminates compression of the egg that normally occurs with conventional ICSI, and thus may reduce the chance of damage. Laser-assisted ICSI is hypothesized to result in increased egg survival, and perhaps improved embryo quality, compared to conventional ICSI.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laser-assisted intracytoplasmic sperm injection | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| oocyte survival rate 1 day after ICSI |
| Measure | Description | Time Frame |
|---|---|---|
| normal fertilization rate 1 day after ICSI | ||
| embryo cell numbers 2 and 3 days after ICSI | ||
| embryo fragmentation rates 2 and 3 days after ICSI |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alana Davis, BS | Shady Grove Fertility Reproductive Science Center | Principal Investigator |
| Kevin S Richter, PhD | Shady Grove Fertility Reproductive Science Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shady Grove Fertility Reproductive Science Center | Rockville | Maryland | 20850 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21560622 | Background | Mikhailusov SV, Bart BIa, Siluianov SV, Mikhailusova MP, Nikolaeva AS. [Duodenogastric reflux and gastric pathology in the elderly patients]. Eksp Klin Gastroenterol. 2010;(12):54-9. Russian. | |
| 21931635 | Background | Kurashige H, Cateau H. Dendritic slow dynamics enables localized cortical activity to switch between mobile and immobile modes with noisy background input. PLoS One. 2011;6(9):e24007. doi: 10.1371/journal.pone.0024007. Epub 2011 Sep 8. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D007248 | Infertility, Male |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D005832 | Genital Diseases, Male |
| D052801 | Male Urogenital Diseases |
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| embryo compaction rate through day 7 after ICSI |
| blastocyst formation rate through day 7 after ICSI |
| 22359603 | Background | Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD. The orphan nuclear receptor LRH-1 and ERalpha activate GREB1 expression to induce breast cancer cell proliferation. PLoS One. 2012;7(2):e31593. doi: 10.1371/journal.pone.0031593. Epub 2012 Feb 16. |
| 22238935 | Background | Semiglazov VF, Paltuev RM, Remizov AS, Semiglazov VV, Dashian GA, Bessonov AA, Pen'kov KD, Vasil'ev AG, Semiglazova TIu, Kolar'kova VV. [The role of nanotechnology in creating novel antitumor agents]. Vopr Onkol. 2011;57(5):636-40. Russian. |
| 15196721 | Background | Rienzi L, Ubaldi F, Martinez F, Minasi MG, Iacobelli M, Ferrero S, Tesarik J, Greco E. Clinical application of laser-assisted ICSI: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2004 Jul 1;115 Suppl 1:S77-9. doi: 10.1016/j.ejogrb.2004.01.017. |