The Incidence, Inheritance, and Prognostic Significance of Polymorphisms in the RASSF1A Gene in Children With Wilms Tumors
The Incidence, Inheritance, and Prognostic Significance of Polymorphisms in the RASSF1A Gene in Children With Wilms Tumors
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young patients with Wilms' tumor.
OBJECTIVES:
Primary
Secondary
OUTLINE: This is a multicenter study. Patients are stratified according to age at diagnosis, stage, histology, site of primary tumor, and outcome.
Genomic DNA samples are purified from peripheral blood of patients and controls and analyzed by polymerase chain reaction for the RASSF1A gene. DNA is also analyzed from parents of patients with the A133S polymorphism.
PROJECTED ACCRUAL: A total of 471 participants (229 Wilms' tumor patients and 200 control participants plus 42 parents) will be accrued for this study.
DISEASE CHARACTERISTICS:
Diagnosis of Wilms' tumor OR
Control participants matched for race, sex, and age
Parents of children involved in the study
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Birmingham, Alabama 35233, United States
Tucson, Arizona 85724, United States
Little Rock, Arkansas 72205, United States
Loma Linda, California 92354, United States
Long Beach, California 90801-1428, United States
Los Angeles, California 90048, United States
Orange, California 92868, United States
Palo Alto, California 94304, United States
San Diego, California 92120, United States
Farmington, Connecticut 06360-7106, United States
Washington D.C., District of Columbia 20007, United States
Gainesville, Florida 32610-0296, United States
Savannah, Georgia 31405, United States
Indianapolis, Indiana 46202-5225, United States
Lexington, Kentucky 40536-0284, United States
New Orleans, Louisiana 70112, United States
Baltimore, Maryland 21201-1595, United States
Baltimore, Maryland 21231-2410, United States
Boston, Massachusetts 02115, United States
Springfield, Massachusetts 01107, United States
Detroit, Michigan 48236, United States
Columbia, Missouri 65212, United States
Omaha, Nebraska 68198-2168, United States
Lebanon, New Hampshire 03756, United States
New Brunswick, New Jersey 08903, United States
Albuquerque, New Mexico 87131, United States
New York, New York 10032, United States
Rochester, New York 14642, United States
Stony Brook, New York 11794, United States
Chapel Hill, North Carolina 27599-7295, United States
Charlotte, North Carolina 28232-2861, United States
Greenville, North Carolina 27858-4354, United States
Winston-Salem, North Carolina 27157-1081, United States
Fargo, North Dakota 58103-4940, United States
Cleveland, Ohio 44106-5065, United States
Oklahoma City, Oklahoma 73104, United States
Portland, Oregon 97227, United States
Portland, Oregon 97239-3098, United States
Hershey, Pennsylvania 17033, United States
Charleston, South Carolina 29425-0721, United States
Sioux Falls, South Dakota 57117-5039, United States
Johnson City, Tennessee 37614-0622, United States
Dallas, Texas 75390-9063, United States
Lackland Air Force Base, Texas 78236, United States
San Antonio, Texas 78229-3902, United States
Richmond, Virginia 23298-0121, United States
Charleston, West Virginia 25302, United States
La Crosse, Wisconsin 54601, United States
St. John's, Newfoundland and Labrador A1B 3V6, Canada
San Juan, 00936-5067, Puerto Rico