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| ID | Type | Description | Link |
|---|---|---|---|
| COG-AREN12B2 | Other Identifier | Children's Oncology Group | |
| CDR0000726713 | Other Identifier | Clinical trials.gov | |
| AREN12B2 | Other Identifier | Children's Oncology Group | |
| NCI-2012-00686 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.
OBJECTIVES:
OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine samples collected at the time of diagnosis and before treatment, are analyzed for molecular and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gene expression analysis | Genetic | |||
| proteomic profiling | Genetic | |||
| reverse transcriptase-polymerase chain reaction | Genetic | |||
| western blotting | Genetic | |||
| immunohistochemistry staining method | Other | |||
| laboratory biomarker analysis | Other | |||
| spectroscopy | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Molecular "finger print" of primary Wilms tumor in ethnically diverse children | ||
| Protein "finger print" from the urine of ethnically diverse children |
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DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Diagnosed with Wilms tumor
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| Name | Affiliation | Role |
|---|---|---|
| Harold N. Lovvorn, III, MD | Vanderbilt Children's Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D007680 | Kidney Neoplasms |
| D009396 | Wilms Tumor |
| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D018193 | Neoplasms, Complex and Mixed |
| D009370 | Neoplasms by Histologic Type |
| D009386 | Neoplastic Syndromes, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D020869 | Gene Expression Profiling |
| D020133 | Reverse Transcriptase Polymerase Chain Reaction |
| D015153 | Blotting, Western |
| D007150 | Immunohistochemistry |
| D013057 | Spectrum Analysis |
| ID | Term |
|---|---|
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D016133 | Polymerase Chain Reaction |
| D021141 | Nucleic Acid Amplification Techniques |
| D004586 | Electrophoresis |
| D002623 | Chemistry Techniques, Analytical |
| D055664 | Electrochemical Techniques |
| D015151 | Immunoblotting |
| D007118 | Immunoassay |
| D007158 | Immunologic Techniques |
| D015336 | Molecular Probe Techniques |
| D006651 | Histocytochemistry |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
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