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| ID | Type | Description | Link |
|---|---|---|---|
| R01MH064735 | U.S. NIH Grant/Contract | View source | |
| DSIR 84-CTP | Other Identifier | NIH | |
| R01MH064503 | U.S. NIH Grant/Contract | View source | |
| R01MH064541 | U.S. NIH Grant/Contract | View source | |
| R01MH064717 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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This study examines the impact of a group cognitive behavioral program aimed at preventing depressive disorders and symptoms in adolescents at risk for developing depression.
Depression is a prevalent, chronic, and impairing condition that is often undetected and becomes more difficult to treat as chronicity increases. There is an increasing need to conduct large-scale depression prevention studies in adolescents. This study evaluates a cognitive-behavioral prevention (CBP) program to determine its effectiveness in preventing depressive disorders in at-risk adolescents. The study also will ascertain the costs this intervention to inform attempts at future dissemination of the program in "real world" settings.
Participants in this study are randomly assigned to receive either CBP for eight weekly and 6 monthly continuation sessions or usual care. Depressive symptoms and disorders, levels of functioning, and medical and mental health care utilization are assessed at baseline and again at 2, 8, 20, and 32 months after intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1= Cognitive behavioral prevention of depression program | Experimental | Participants receive a group cognitive-behavioral prevention program, which involved 8 weekly sessions and 6 monthly sessions of CBT skills such as cognitive restructuring, problem-solving, assertivenss, and behavioral activation. Participants in this arm also were able to seek the same kinds of nonstudy treatments as described in the usual care arm. |
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| 2 = Usual care | Active Comparator | Participants receive usual care, which involves any type of treatment (e.g., psychotherapy, counseling, pharmacotherapy). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive-behavioral prevention program | Behavioral | Cognitive-behavioral prevention program includes 8 weekly and 6 monthly group sessions. |
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| Measure | Description | Time Frame |
|---|---|---|
| Onset of a probable or definite depressive episodes (i.e., Depression Symptom Rating greater or equal to 4) | a score of 4 or greater is considered an onset | Time to a score of 4 or higher between baseline and 9 months using survival analysis |
| Measure | Description | Time Frame |
|---|---|---|
| Number of depression-free days | Using the depression symptom ratings (DSR) (1-6), each week is given a score of 1 to 6; depression-free days are those with ratings of 1 or 2 on the DSR. | Measured continuously through Month 33 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Judy Garber, PhD | Vanderbilt University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harvard University Medical School | Boston | Massachusetts | 02115-5794 | United States | ||
| Kaiser Permanente Center for Health Research |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19491183 | Result | Garber J, Clarke GN, Weersing VR, Beardslee WR, Brent DA, Gladstone TR, DeBar LL, Lynch FL, D'Angelo E, Hollon SD, Shamseddeen W, Iyengar S. Prevention of depression in at-risk adolescents: a randomized controlled trial. JAMA. 2009 Jun 3;301(21):2215-24. doi: 10.1001/jama.2009.788. | |
| 24005242 | Result | Beardslee WR, Brent DA, Weersing VR, Clarke GN, Porta G, Hollon SD, Gladstone TR, Gallop R, Lynch FL, Iyengar S, DeBar L, Garber J. Prevention of depression in at-risk adolescents: longer-term effects. JAMA Psychiatry. 2013 Nov;70(11):1161-70. doi: 10.1001/jamapsychiatry.2013.295. |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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Outcome assessor were unaware of condition assignment
| Usual care | Other | Participants receive usual care |
|
| Portland |
| Oregon |
| 97227 |
| United States |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213-2593 | United States |
| Vanderbilt University | Nashville | Tennessee | 37203-5721 | United States |
| 26421861 | Result | Brent DA, Brunwasser SM, Hollon SD, Weersing VR, Clarke GN, Dickerson JF, Beardslee WR, Gladstone TR, Porta G, Lynch FL, Iyengar S, Garber J. Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559. |
| 30929618 | Derived | Lynch FL, Dickerson JF, Clarke GN, Beardslee WR, Weersing VR, Gladstone TRG, Porta G, Brent DA, Mark TL, DeBar LL, Hollon SD, Garber J. Cost-Effectiveness of Preventing Depression Among At-Risk Youths: Postintervention and 2-Year Follow-Up. Psychiatr Serv. 2019 Apr 1;70(4):279-286. doi: 10.1176/appi.ps.201800144. Epub 2019 Jan 3. |
| 26903255 | Derived | Weersing VR, Shamseddeen W, Garber J, Hollon SD, Clarke GN, Beardslee WR, Gladstone TR, Lynch FL, Porta G, Iyengar S, Brent DA. Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects. J Am Acad Child Adolesc Psychiatry. 2016 Mar;55(3):219-26. doi: 10.1016/j.jaac.2015.12.015. Epub 2016 Jan 18. |