Assessment of Potential Interactions Between Methamphetamine and Selegiline - 1

Assessment of Potential Interactions Between Intravenous Methamphetamine and Oral Selegiline

The purpose of this study is to assess the potential interactions between intravenous methamphetamine and oral selegiline.

To determine the safety of the selegiline concurrent with d-methamphetamine challenges of 15mg & 30mg i.v. with the focus being on cardiovascular responses (HR,BP) to the i.v. methamphetamine challenges. This is a randomized, single-blind, placebo-controlled, two-arm study design to evaluate the safety of selegiline treatment, compared to placebo treatment, concurrent with i.v. methamphetamine challenges.

Inclusion Criteria:

• Volunteers who meet DSM-4 criteria for methamphetamine abuse or dependence; non-treatment seeking individuals
• Be able to verbalize understanding of consent form; provide written informed consent

Exclusion Criteria:

• Please contact site for more information