Assessment of Potential Interactions Between Cocaine and Tolcapone - 1

Assessment of Potential Interactions Between Intravenous Cocaine and Tolcapone

The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.

Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.

Inclusion Criteria:

Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence

Exclusion Criteria:

Additional criteria available during screening at the site