Comparative Efficacy of Alpha Hydroxy Acids With and Without Nanocarriers Versus Calcipotriol Plus Betamethasone in Treatment of Plaque Psoriasis

Comparative Efficacy of Alpha Hydroxy Acids With and Without Nanocarriers Versus Calcipotriol Plus Betamethasone in Treatment of Plaque Psoriasis

The aim of this double blind comparative clinical study is to evaluate the efficacy of AHAs combined with nanocarriers and their use as a non steroidal alternative drug for long term management of plaque psoriasis

Inclusion Criteria:- Mid to moderate cases according to Psoriasis Area and Severity Index (PASI).

• Age from18-65 years old.
• Denovo psoriatic patients and patients with no psoriasis therapy in the previous two months.

Exclusion Criteria:

• Severe irritation and highly inflamed skin.
• Pregnant and lactating females.
• Patients with acute renal insufficiency.
• Face, flexural and groin lesions.