Steroids in the Treatment of Deep Neck Space Infections

Efficacy and Safety of Steroids in the Treatment of Deep Neck Space Infections: A Double-Blind, Randomized, Placebo-Controlled Trial

This randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of dexamethasone as an adjunct to standard treatment in patients with deep neck infections. Participants were randomly assigned to receive either a single intravenous dose of 8 mg dexamethasone or placebo in addition to standard treatment. The study evaluated changes in pain severity, interincisor distance, and body temperature, as well as the time to pain-free swallowing. Participants were followed from baseline through Day 7.

Inclusion Criteria:

• age 18 years or older
• diagnosis of a deep neck space infection confirmed by clinical examination and contrast-enhanced computed tomography
• provision of written informed consent

Exclusion Criteria:

• Isolated peritonsillar abscess
• Age younger than 18 years
• Systemic corticosteroid use before enrollment
• Hospitalization for a diagnosed or suspected deep neck infection within the preceding 30 days