Hair Regrowth Following Partial Thickness Removal of SSCIS

Hair Regrowth Following Partial Thickness Stages in Mohs Micrographic Surgery of Squamous Cell Carcinoma in Situ: A Prospective Pilot Study

Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.

Inclusion Criteria:

• Adults ≥ 18 years old
• Histologically confirmed SCCIS
• Lesions located in the hair-bearing scalp
• Ability to provide informed consent

Exclusion Criteria:

• Invasive, poorly differentiated, or high-risk SCC features (e.g., perineural invasion)
• Recurrent SCC at the same site
• Prior radiation therapy to the scalp
• Scarring alopecia or active inflammatory scalp disease at the treatment site
• Immunosuppression that, in the investigator's judgement, increases oncologic risk
• Use of topical minoxidil, oral minoxidil, finasteride, spironolactone, or other hair-growth promoting agents