Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

ClinicalTrials.gov ID

NCT07805967

Lead Sponsor

Second Affiliated Hospital of Soochow UniversityOTHER

Overall Status

Recruiting

Study Type

Observational

Enrollment

500Estimated

Last Update Posted

Sep 8, 2026Actual

Start Date

Nov 12, 2025Actual

Primary Completion Date

Aug 31, 2030Estimated

Completion Date

Aug 31, 2030Estimated

Official Title

Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

Brief Summary

This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.

• Multiple System Atrophy
• Dementia With Lewy Bodies (DLB)
• Progressive Supranuclear Palsy (PSP)
• Corticobasal Degeneration (CBD)

• We did not apply any interventions; only observational research was conducted.

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

1. MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) .
2. DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) .
3. PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years .
4. CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb).

Exclusion Criteria:

1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure .
2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .

Observational Model

Cohort

Time Perspective

Prospective

Lead Sponsor

Second Affiliated Hospital of Soochow UniversityOTHER

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