Oral Verapamil Among Newly Diagnosed Children and Adolescents With Type 1 Diabetes

Efficay and Safety of Oral Verapamil on Glycemic Metrics and ß-cell Reserve Among Newly Diagnosed Children and Adolescents With Type 1 Diabetes

Type 1 diabetes (T1D) in children involves autoimmune destruction of pancreatic ß- cells, leading to insulin deficiency. Verapamil is an L-type calcium channel blocker that has been used for decades to treat hypertension and certain cardiac conditions. Recent research has revealed its potential as a ß- cell-protective agent. Hence this study will evaluate the effect of once-daily oral verapamil on pancreatic ß- cell reserve , glycemic metrics and daily insulin requirements in children and adolescents with T1D.

Inclusion Criteria:

• Children and adolescents aged 10-18 years.
• Newly diagnosed type 1 diabetes mellitus (within 6 weeks of diagnosis, defined as the day of starting insulin therapy).
• Presence of at least two positive islet autoantibody (anti glutamic acid decarboxylase antibodies, anti- tyrosine phosphataseantibodies ,anti- zinc transporter 8 protein antibodies , or anti-insulin antibodies).
• Ability to comply with study procedures.

Exclusion Criteria:

• Previous diagnosis of other endocrine disorders or autoimmune disorder (e.g. autoimmune thyroiditis).
• Current or planned use of medications that might affect glucose metabolism (e.g., corticosteroids, immunomodulators).
• Known allergy or intolerance to verapamil.
• Cardiac conduction abnormalities, heart block, or significant cardiac disease.
• Systolic or diastolic blood pressure < 5th percentile for age and gender.
• Severe hepatic or renal impairment.
• Participation in another interventional clinical trial.
• Inability to follow the protocol for any reason as determined by the investigator.
• Elevated liver enzymes >1.5 × upper limit of normal at screening