Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

ClinicalTrials.gov ID

NCT07804446

Lead Sponsor

University of ChicagoOTHER

Overall Status

Recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

140Estimated

Last Update Posted

Sep 4, 2026Actual

Start Date

Aug 31, 2026Actual

Primary Completion Date

Apr 1, 2027Estimated

Completion Date

May 1, 2027Estimated

Official Title

Does Injection Site (Anteromedial vs Anterolateral) Affect Pain Relief After Intra-Articular Corticosteroid Injection in Moderate-to-Severe Medial Knee Osteoarthritis?

Brief Summary

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

1. Be randomly divided into getting their steroid injection on the inside or outside of their knee.
2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

• Osteoarthitis
• Osteoarthritic Knee Pain
• Osteoarthritis (OA)
• Osteoarthritis (OA) of the Knee
• Osteoarthritis in the Knee

• Anteromedial Injection
• Anterolateral Injection

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Age ≥ 40
• Clinical diagnosis of knee OA with predominant medial compartment symptoms
• Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
• Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
• Able to provide informed consent
• Able to complete phone, email, or MyChart follow-ups in English

Exclusion Criteria:

• Predominant lateral compartment OA or patellofemoral-only OA
• Inflammatory arthritis (RA, gout flare, etc.)
• Suspected or confirmed joint infection or overlying cellulitis
• Prior knee arthroplasty on the index knee
• Planned surgery for index knee within 12-week follow-up
• Inability to complete follow-up assessments
• Other clinician-determined contraindication to CSI

Primary Purpose

Treatment

Allocation

Randomized

Interventional Model

Parallel Assignment

Masking

None (Open Label)

Lead Sponsor

University of ChicagoOTHER

Collaborators

AdventHealthOTHER

swallace2@bsd.uchicago.edu773-834-3531

swallace2@bsd.uchicago.edu773-834-3531

swallace2@bsd.uchicago.edu888-824-0200

brandon.pardi.md@adventhealth.com630-759-1248

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