ALDH2 rs671, Alcohol Use, and Health Education in University Students

Investigation of the Relationship Between rs671 Polymorphism and Attitudes and Behaviors Toward Drinking and Effectiveness of Health Education

Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.

Inclusion Criteria:

• Currently enrolled as a student at National Taiwan University
• Aged 18 to 65 years

Exclusion Criteria:

• None