Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H

Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes

To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in healthy individuals, who live permanently >2600m.

The aim of this research is to investigate the heart rate variability and other hemodynamic outcomes during the descent from 2850m to sea level and during re-ascent from sea level to 2850m in healthy individuals, who permanently live at high altitude over 2600m

Inclusion Criteria:

• Adults aged 18-80 years and of all genders
• Permanent residence > 2600 m
• healthy: no self perceived cardiopulmonary disease limiting daily activities
• written informed consent to participate in the study.

Exclusion Criteria:

• Age <18 years or >80 years
• Participants who cannot follow the study investigations
• Participants permanently living < 2600m
• Participants who traveled and stayed overnight at altitudes <2000 m in the past 4 weeks.
• any self-perceived cardiopulmonary disease limiting daily activities