Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging

ClinicalTrials.gov ID

NCT07799740

Lead Sponsor

University of AarhusOTHER

Overall Status

Not yet recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

100Estimated

Last Update Posted

Sep 11, 2026Actual

Start Date

Sep 1, 2026Estimated

Primary Completion Date

May 1, 2029Estimated

Completion Date

Jun 1, 2029Estimated

Official Title

Laser Speckle Contrast Imaging for Rectal Anastomotic Evaluation (LIRA): A Feasibility Study.

Brief Summary

This multicentre feasibility study evaluates the feasibility of performing laparoscopic Laser Speckle Contrast Imaging (LSCI) measurements of rectal perfusion during rectal cancer surgery. To our knowledge, LSCI has not previously been applied laparoscopically for intraoperative assessment of rectal perfusion in this setting. Laparoscopic LSCI measurements will be compared with indocyanine green fluorescence imaging, and associations between quantitative measures of colorectal perfusion and postoperative outcomes, including anastomotic leakage, will be explored.

• Rectal Cancer
• Total Mesorectal Excision
• Laser Speckle Contrast Imaging
• Indocyanine Green (ICG)
• Optical Imaging

• Laser speckle contrast imaging

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Age ≥ 18 years
• Rectal cancer
• Surgical strategy either partial or total mesorectal excision
• Able to provide informed consent

Exclusion Criteria:

- Allergy to iodine

Primary Purpose

Other

Allocation

N/A

Interventional Model

Single Group Assignment

Masking

None (Open Label)

Lead Sponsor

University of AarhusOTHER

Collaborators

Gødstrup HospitalOTHER

Vejle HospitalOTHER

pernille.oehlenschlager.larsen0@rsyd.dk+45 79 40 56 04

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