Understanding Information Preferences, Risk Perceptions, and Tradeoffs When Making Decisions About Multi-cancer Early Detection Tests

Investigating Information Preferences, Risk Perceptions, and Tradeoffs in Multi-Cancer Early Detection Decisions: A Randomized Vignette Trial

The goal of this clinical trial is to learn what people's informational preferences and risk perceptions are in regards to the use of multi-cancer early detection (MCED) tests. Participants will be asked to review three informational factors about MCED tests and complete a survey about their intentions to use an MCED test. Some participants will also be asked to complete an interview.

This is a clinical trial using a randomized vignette design where the vignette sequentially introduces 3 information factors to participants. This allows for the effect of each informational factor to be tested in the context of the preceding sequence of factors. In this study, the investigators will deliver the vignette in three phases, varying the level of detail of one factor in each phase, resulting in 8 combinations of study conditions. Participants will be randomly assigned to these conditions and repeated measures of outcomes of interest will be derived from survey assessments conducted after each informational factor is presented. At the end of trial participation, respondents will be invited to participate in one qualitative interview lasting 30-45 minutes.

Inclusion Criteria:

• Aged 40-74
• Speak English or Spanish

Exclusion Criteria:

• Prior diagnosis of cancer (with the exception of non-melanoma skin cancers)
• Previous use of a Multi-Cancer Early Detection (MCED) test.