Multimodal Laser Treatment of Photodamaged Skin

Multimodal Laser Treatment of Photodamaged Skin

The Multimodal Laser Project is a prospective, randomized, split-face clinical study investigating a novel combination of laser and light-based treatments for facial photodamage with the long-term perspective of improving skin cancer prevention.

The study includes 35 patients with facial photodamage and AKs. One side of the face receives a multimodal treatment combining three complementary technologies: 1927-nm thulium laser, 1550-nm non-ablative fractional laser, and intense pulsed light (IPL), while the contralateral side serves as an untreated control.

Participants are followed for 14 months to assess both clinical efficacy and longer-term preventive effects.

The overall aim is not only to determine whether multimodal laser treatment improves photodamaged skin, but also to gain a deeper understanding of how the treatment affects the underlying biology of chronically sun-damaged skin and its potential role in skin cancer prevention.

Inclusion Criteria:

• Age ≥18 years
• Clinical signs of facial photodamage, including low-grade actinic keratosis (Olsen grade I-II) , solar lentigines, mottled hyper- and hypopigmentation, telangiectasia, skin thinning or atrophy, loss of skin elasticity (solar elastosis), coarse, leathery texture

Exclusion Criteria:

• Fitzpatrick skin type ≥ 4
• Active skin disease in the treatment area that may interfere with study treatment or assessments
• Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments
• Pregnancy or breastfeeding
• Contraindications to the three lasers or topical anesthetics
• Fitzpatrick skin type ≥ 4
• Active skin disease in the treatment area that may interfere with study treatment or assessments
• Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments
• Pregnancy or breastfeeding
• Contraindications to the three lasers or topical anesthetics