Multi-Field-Strength MRI Brain Atlas Construction in Healthy Chinese Population

Multi-Field-Strength MRI Brain Atlas Construction in Healthy Chinese Population

This prospective imaging study aims to construct a multi-field-strength magnetic resonance imaging (MRI) brain atlas for healthy Chinese adults. Healthy volunteers will undergo standardized brain MRI examinations at multiple magnetic field strengths, including 0.55T, 1.5T, 3T, 5T, and 7T. Structural, diffusion, functional, and other quantitative MRI data will be acquired and analyzed. The study will characterize the consistency and differences in brain morphology and imaging measurements across field strengths and establish standardized multi-field-strength brain templates and reference data for healthy Chinese adults.

This is a prospective multi-field-strength neuroimaging study involving healthy Chinese adults. Eligible participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T according to the study protocol.

MRI acquisitions include structural imaging, diffusion imaging, functional imaging, and quantitative imaging sequences where applicable. Images will undergo standardized preprocessing, registration, segmentation, and quantitative analysis. Multi-field-strength brain templates will be constructed, and anatomical and functional imaging characteristics will be compared across magnetic field strengths.

The study aims to establish normative multi-field-strength MRI reference data and brain atlases for healthy Chinese adults and to evaluate the consistency and field-strength-related differences in brain morphometry, cortical measurements, diffusion characteristics, functional connectivity, and other quantitative MRI parameters.

Inclusion Criteria:

• Aged 16 to 66 years. Voluntarily participates in the study and provides written informed consent. No contraindications to MRI examination and able to cooperate with and complete the MRI examinations.

Female participants must not be pregnant. No current or previous clinical diagnosis of severe neurological or psychiatric disorders, such as schizophrenia, dementia, epilepsy, or severe sequelae of traumatic brain injury.

No obvious intracranial lesions or structural abnormalities identified on routine MRI examination.

Exclusion Criteria:

• Presence of contraindications to MRI examination, including MRI-incompatible implanted metallic or electronic devices, cochlear implants, cardiac pacemakers, intracranial metallic clips, or similar devices.

Severe claustrophobia preventing completion of the MRI examination. Pregnancy. Current or previous clinical diagnosis of severe neurological or psychiatric disorders.

History of severe head trauma, brain tumor, stroke, brain surgery, or other conditions that may substantially affect brain structure or function.

MRI data of insufficient quality for analysis due to marked discomfort, excessive head motion, or other causes during the examination.