Closed-loop TBS Targeting rPO for the Core Clinical Features of the Methamphetamine Use Disorder

A Pilot Single-Arm Study of Closed-Loop TBS Theta-Burst Stimulation Targeting the Right Parietal-Occipital Cortex for Core Clinical Features of Methamphetamine Use Disorder

The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use disorder (MUD), such as cue-reactivity and impaired inhibitory control.

The main questions it aims to answer are:

Can closed-loop rPO-TBS significantly reduce cue-reactivity, as measured by a Visual Analog Scale (VAS) and a cue-reactivity task? Does closed-loop stimulation enhance cognitive control, assessed by performance on the Stop Signal Task (SST)?

Researchers will administer closed loop TBS to determine whether it can improve the core symptoms of MUD.

Participants will:

Complete a single closed-loop sessions. Receive theta-burst stimulation targeting the right parietal-occipital cortex while complete the cue-reactivity task.

Undergo cue-reactivity assessment using a Visual Analog Scale (VAS) and complete the Stop Signal Task (SST) before and after the stimulation session.

Inclusion Criteria:

• Aged 18 years old or older, ....with at least 9 years of education (junior high school or above) or able to fully understand the task.
• Meets DSM-5 for mild/severe amphetamine-type substance use disorder.
• History of amphetamine-type substance use for no less than 1 year, with use at least once per week.
• Has not received pharmacological treatment for substance use.

Exclusion Criteria:

• Presence of any organic disease, or diagnosis of any other psychiatric disorder according to DSM-5 (e.g., bipolar disorder, major depression disorder).
• Contraindications to TMS, as assessed by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS).
• Inability to complete assessments, treatment procedures, or follow-up due to cognitive or behavioral limitations.