Efficacy Validation of Deep Microspicule Cream for Anti-aging and Whitening on Mature Skin

Efficacy Validation of Deep Microspicule Cream for Anti-aging and Whitening on Mature Skin

This study is a single-center, prospective, split-face self-controlled pilot trial designed to evaluate the anti-aging and whitening efficacy of the "Deep Microspicule Cream" (containing patented crystal microspicules encapsulating Penghu seaweed extract) on mature skin.

This study is a single-center, prospective, split-face self-controlled pilot trial.

10 healthy participants aged 40-65 who present signs of skin aging or hyperpigmentation will be enrolled.

Intervention Side (Active): Participants will apply a green-bean-sized amount of Deep Microspicule Cream on the assigned side, gently massaging to let the microspicules roll on the skin, followed by the application of Deep Essence to dissolve the microspicules.

Control Side: Participants will apply Deep Essence only. The applications are performed 3 times per week at bedtime. Clinical evaluations and instrument measurements are scheduled at Day 0 (baseline), Day 14, and Day 28. On assessment days, participants must cleanse their faces and rest in a controlled environment for 25-30 minutes without applying any cosmetics before undergoing non-invasive skin assessments.

Inclusion Criteria:

• Healthy male or female participants aged 40-65 years.
• Presence of at least one facial aging or hyperpigmentation feature (e.g., eye area sagging, eye bags, crow's feet, fine lines, freckles, sun spots, uneven skin tone, or dullness).
• Willing to complete 3 study visits within 4 weeks, comply with instrumental measurements, and maintain product logs.
• Willing to sign the Informed Consent Form (ICF).

Exclusion Criteria:

• Received facial aesthetic treatments (e.g., lasers, chemical peels, microneedling, energy-based therapies) within 4 weeks.
• Used topical/oral retinoic acid or strong whitening creams (e.g., high-concentration hydroquinone) within 4 weeks.
• Severe sensitive skin, active atopic dermatitis, or obvious facial skin lesions/infections.
• Facial salon or exfoliation treatments more frequent than once every 2 weeks.
• Known allergy to seaweed-derived ingredients or product preservative systems.
• Uncontrolled systemic diseases (e.g., diabetes, kidney/liver/cardiovascular diseases, severe infections, endocrine disorders, or cancer).
• Pregnant, lactating, or planning to become pregnant.
• Deemed unsuitable for participation by the investigator.