Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis | NCT07774195 | Trialant

Not yet recruitingInterventionalNot ApplicableUpdated Aug 19, 2026

Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis

Overview

Key facts that identify this study and show where it stands today.

ClinicalTrials.gov ID: NCT07774195
Lead Sponsor: Cairo UniversityOTHER
Overall Status: Not yet recruiting
Study Type: Interventional
Phase: Not Applicable
Enrollment: 40Estimated
Last Update Posted: Aug 19, 2026Actual
Start Date: Aug 21, 2026Estimated
Primary Completion Date: Nov 21, 2026Estimated
Completion Date: Nov 30, 2026Estimated

Description

What the study is about and why it is being run, in the researchers' own words.

Official Title: Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis
Brief Summary: This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.

Forty patients with knee osteoarthritis will be randomly assigned to one of two groups. The traditional physical therapy group will receive a conventional rehabilitation program including transcutaneous electrical nerve stimulation (TENS), strengthening, flexibility, and balance exercises. The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4 based on standardized patient information and clinical assessment findings.

Both groups will receive education regarding lifestyle modification and joint protection strategies. The effects of the two rehabilitation approaches will be evaluated by measuring pain intensity, knee range of motion, knee-related functional ability, and functional mobility and fall risk before and after the intervention.

The study will determine whether an AI-guided physical therapy program can provide outcomes comparable or superior to those of traditional physical therapy in individuals with knee osteoarthritis.

Conditions

The medical conditions and diseases this study investigates.

Knee Osteoarthritis

Interventions

The treatments and procedures being evaluated in this study.

AI-Guided Physical Therapy Program
Traditional Physical Therapy Program
Lifestyle Modification and Joint Protection Education

Participation

Who can join this study and the criteria used to decide.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Participants will be recruited through outpatient orthopedic clinics and community health centers affiliated with the study sites.

Their age will be ranged from 45-70 years.

Their body mass index (BMI) will be ranged from 24.9 to 30 kg /m2 .

With a clinical and radiographic diagnosis of knee osteoarthritis based on American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis, and who will able to ambulate

Independently walk without assistive devices.

Exclusion Criteria:

Prior knee replacement surgery, inflammatory arthritis (e.g., rheumatoid arthritis).

Recent intra-articular steroid injections within three months.

Neurologic impairments affecting lower limb function.

Inability to comprehend or use the mobile application due to cognitive or sensory impairments.

Design

How the study is designed and how its participant groups are organized.

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Single

Contacts

The people to reach with questions about this study or how to join it.

Marina Hosny Raghep, B.ScContact

Marinahosny2895@gmail.com+20 12 71739917

Locations

Where the study is run and whether each site is currently recruiting.

Faculty of physical therapy, Cairo University

Giza, Egypt

Collaborators

The organizations and people involved in this study.

Lead Sponsor: Cairo UniversityOTHER

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Other registered studies that closely resemble this one.

Detailed Description

This study is a prospective, single-blind, randomized controlled trial designed to compare the efficacy of an AI-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.

A total of 40 patients with knee osteoarthritis will be recruited from the Outpatient Clinic of the Faculty of Physical Therapy, Cairo University. Eligible participants will be aged 45-70 years and diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis. Participants will be randomly allocated into two equal groups.

The control group will receive a conventional physical therapy program consisting of transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. Treatment will be provided three times per week for 12 weeks.

The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4. Standardized patient information, including age, sex, pain intensity, functional disability, knee range of motion, symptom duration, and physical activity level, will be entered by the researcher to generate an evidence-based rehabilitation program for each participant.

Both groups will also receive education regarding lifestyle modification and joint protection strategies.

Outcome measures will be assessed before and after the intervention. Pain intensity will be evaluated using the Visual Analog Scale (VAS), knee range of motion using a digital goniometer, knee-related pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and functional mobility and fall risk using the Timed Up and Go (TUG) test.

The study will compare changes in these outcomes between the two groups to determine the relative efficacy of AI-guided and traditional physical therapy programs for patients with knee osteoarthritis.