Two-photon Fluorescence Microscopy of Dermatologic Biopsies | NCT07773688 | Trialant

RecruitingInterventionalNot ApplicableUpdated Aug 19, 2026

Two-photon Fluorescence Microscopy of Dermatologic Biopsies

Expanded Two-photon Imaging of Skin Biopsy Specimens

Overview

Key facts that identify this study and show where it stands today.

What the study is about and why it is being run, in the researchers' own words.

Official Title: Expanded Two-photon Imaging of Skin Biopsy Specimens
Brief Summary: The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are:

• How well do two-photon fluorescence images of biopsies taken in a clinic and evaluated by a pathologist agree with conventional histology?
Detailed Description: This study will image biopsy specimens using two-photon fluorescence microscopy (TPFM) and then assess how well the images predict the eventual clinical diagnosis using both an expert pathologist and a machine learning model. Because two-photon images can be acquired from small biopsy specimens within minutes of excision, they could potentially be used to immediately diagnose patients, but the accuracy of TPFM for various skin conditions is unknown.

Individual biopsy specimens in a clinic lab will be imaged using TPFM. Following histological processing and patient treatment, resulting histology slides will be scanned for comparison. Images of the histology slides will be read by a pathologist to establish a gold-standard diagnosis and the official diagnosis will be recorded. TPFM images will be evaluated by a pathologist and concordance with the gold-standard determined.

The medical conditions and diseases this study investigates.

The treatments and procedures being evaluated in this study.

Who can join this study and the criteria used to decide.

Ages Eligible for Study: Child (0-17)Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Punch, excisional or shave biopsy specimen

Exclusion Criteria:

Biopsies composed of multiple excisions or pieces

How the study is designed and how its participant groups are organized.

The people to reach with questions about this study or how to join it.

Michael G Giacomelli, Ph.DContact

mgiacome@ur.rochester.edu5852766260

Where the study is run and whether each site is currently recruiting.

Rochester Dermatologic SurgeryRecruiting

Victor, New York 14654, United States

The organizations and people involved in this study.

Other registered studies that closely resemble this one.