Inclusion Criteria:

• Adults aged 18 years or older Previously known oncological disease Histologically confirmed diagnosis of high-grade MIBC Non-muscle-invasive, or low-grade bladder cancer

Eligible for platinum-based neoadjuvant treatment on clinical evaluation:

• ECOG performance status of 0-1,
• creatinine clearance of at least 60 mL/min,
• absence of comorbidities that would contraindicate chemotherapy (such as grade ≥2 neuropathy, grade ≥2 hearing impairment, or significant cardiopathy) Impossibility to perform imaging procedures, including
• Claustrophobia
• history of iodinated contrast medium allergy precluding ceCT
• diabetes uncontrolled by medications Sign of informed consent

Exclusion Criteria:

• Adults aged 18 years or older Previously known oncological disease Histologically confirmed diagnosis of high-grade MIBC Non-muscle-invasive, or low-grade bladder cancer

Eligible for platinum-based neoadjuvant treatment on clinical evaluation:

• ECOG performance status of 0-1,
• creatinine clearance of at least 60 mL/min,
• absence of comorbidities that would contraindicate chemotherapy (such as grade ≥2 neuropathy, grade ≥2 hearing impairment, or significant cardiopathy) Impossibility to perform imaging procedures, including
• Claustrophobia
• history of iodinated contrast medium allergy precluding ceCT
• diabetes uncontrolled by medications