Inclusion Criteria:

• Male or female participants aged 18 years or older.
• Able to understand the study requirements and voluntarily provide written informed consent before any study-specific procedures.
• Histologically or cytologically confirmed advanced or metastatic EGFR-positive and PD-L1-positive solid tumor that has progressed following standard therapy, is intolerant to standard therapy, or for which no effective standard therapy is available, including but not limited to head and neck squamous cell carcinoma, non-small cell lung cancer, unresectable advanced colorectal cancer, and renal clear cell carcinoma.
• Able to provide archived tumor tissue or other tumor samples as required by the protocol during the screening period.
• At least one measurable lesion according to RECIST Version 1.1.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Life expectancy of at least 12 weeks.
• Adequate hematologic, hepatic, renal, cardiac, and other organ function as defined in the protocol.
• Left ventricular ejection fraction (LVEF) greater than 50% as determined by echocardiography (ECHO) or multigated acquisition (MUGA) scan.
• Female participants of childbearing potential must have a negative serum pregnancy test within 7 days before the first dose of study treatment.
• Male participants and female participants of childbearing potential must agree to use highly effective contraception during the study and for at least 6 months after the last dose of study treatment.

Exclusion Criteria:

• Insufficient washout period from prior anticancer therapy before the first dose of study treatment.
• Prior anticancer immunotherapy permanently discontinued due to immune-related toxicity, history of Grade 3 or higher immune-related adverse events (irAEs), or history of Grade 2 or higher immune-related myocarditis considered by the investigator to make the participant unsuitable for study participation.
• History of severe infusion-related reactions associated with prior EGFR-targeted therapy.
• Receipt of antitumor vaccines or cellular immunotherapy within 3 months before the first dose of study treatment.
• Presence of another active malignancy requiring treatment.
• Adverse events from prior anticancer therapy that have not recovered to Grade 1 or baseline, except for alopecia, skin pigmentation of any grade, or Grade 2 or lower peripheral sensory neuropathy.
• Active autoimmune disease requiring systemic immunosuppressive therapy.
• Major surgery, open biopsy, or significant traumatic injury within 4 weeks before the first dose; planned major surgery during the study; or incomplete recovery from prior surgery.
• Active central nervous system (CNS) tumors.
• Symptomatic heart failure (New York Heart Association Class II or higher).
• Uncontrolled hypertension (systolic blood pressure greater than 150 mmHg or diastolic blood pressure greater than 100 mmHg despite optimal medical therapy).
• Fridericia-corrected QT interval (QTcF) greater than 470 milliseconds based on the average of triplicate screening electrocardiograms.
• Acute coronary syndrome, acute myocardial infarction, unstable angina, percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG) surgery within 6 months before the first dose.
• Cardiomyopathy of any etiology or clinically significant valvular heart disease.
• Clinically significant arrhythmias requiring medical treatment (well-controlled atrial fibrillation is permitted).
• Transient ischemic attack (TIA) or stroke within 6 months before screening.
• Uncontrolled pleural effusion, pericardial effusion, or ascites requiring drainage at least once per month or ongoing clinical intervention.
• Active infection requiring systemic antibacterial or antiviral therapy within 14 days before the first dose. Participants receiving stable antiviral therapy for hepatocellular carcinoma or controlled hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are permitted.
• Active or uncontrolled hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Participants with controlled HBV or HCV receiving stable antiviral therapy may be eligible.
• Known human immunodeficiency virus (HIV) infection.
• Receipt of systemic immunosuppressive medication within 14 days before the first dose, unless permitted by the protocol.
• History of interstitial lung disease (ILD), pneumonitis, suspected ILD or pneumonitis that cannot be excluded by screening imaging, or severe chronic obstructive pulmonary disease (COPD).
• History of severe hypersensitivity to monoclonal antibodies or history of anaphylaxis within 6 months before screening.
• History of allogeneic organ transplantation or graft-versus-host disease (GvHD).
• Receipt of a live vaccine within 4 weeks before the first dose.
• Known substance abuse or psychiatric disorder that, in the opinion of the investigator, would interfere with study participation or protocol compliance.
• Pregnant or breastfeeding women, or participants planning to conceive or father a child during the study and for at least 6 months after the last dose of study treatment.
• Any medical condition, laboratory abnormality, or other clinical circumstance that, in the opinion of the investigator, would make the participant unsuitable for study participation or could interfere with the interpretation of study results.