Derivation and External Validation of the "FORECAST-PC" Prediction Scores | NCT07750015

NCT07750015

Overview

NCT ID: NCT07750015
Lead Sponsor: Dr. med. Alexander Salerno, MD-PhDOTHER
Official Title: Machine Learning Models Predict 90-Day Functional Outcome in Posterior Circulation Thrombectomy: Derivation and External Validation of the "FORECAST-PC" Prediction Scores
Brief Summary: This study aims to develop and externally validate machine learning prediction models (FORECAST-PC) to determine 90-day functional outcomes for patients suffering from acute ischemic stroke in the posterior circulation who are selected for endovascular thrombectomy (EVT)
Conditions: Posterior Ischemic Stroke
Cerebral Infarction
Cerebrovascular Disorders
Interventions

Status and Timeline

Status: Completed
Last Update Posted: Aug 6, 2026Actual
Start Date: Jan 1, 2015Actual
Primary Completion Date: Dec 31, 2024Actual
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Age > 18 years

Presentation with acute ischemic stroke (AIS) attributed to a radiologically confirmed posterior circulation occlusion

Selected for Endovascular Thrombectomy (EVT) according to the treating physician

Pre-stroke modified Rankin Scale (mRS) 0-3

EVT initiated or attempted within 24-hours of the last known well (LKW) time

Includes cases with/without prior intravenous thrombolysis (IVT), mothership, and drip-and-ship pathways

Exclusion Criteria:

EVT carried out beyond 24 hours from stroke onset

EVT performed secondarily after in-hospital worsening or stroke recurrence

In-hospital strokes (to avoid the confounding influence of prior systemic comorbidities and the acute event that necessitated initial admission)

Missing primary outcome data

Inconsistencies between descriptive dependence status and raw pre-stroke mRS

Stroke cases occurring prior to 2015 (to account for major changes in endovascular treatment techniques)

Study Plan

Study Type: Observational
Phase: No data available
Enrollment: 732Actual
Primary Purpose: No data available
Allocation: No data available
Interventional Model: No data available
Masking

Contacts and Locations

Central Contacts: No data available
Locations: Centre Hospitalier Universitaire Vaudois

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