Inclusion Criteria:

• (1)Patients

  1. Eligible for radical lung cancer surgery confirmed by clinicians in accordance with lung cancer clinical guidelines;

  2. Aged over 18 years old;

  3. No history of drug or alcohol dependence, and no use of contraceptives or hormones within the past three months;

  4. Fully informed of the study, signed informed consent and volunteered to participate.

     (2)Family Caregivers

  1. Spouses, adult children or other relatives who provide long-term unpaid daily care and companionship for patients;
  2. Aged over 18 years old;
  3. No history of drug or alcohol dependence, and no use of contraceptives or hormones within the past three months;
  4. Fully informed of the study, signed informed consent and volunteered to participate.

Exclusion Criteria:

• (1)Patients:

  1. Patients who do not meet the surgical indications as evaluated by clinicians;

  2. Patients with immune system diseases;

  3. Patients with a history of mental illness or severe cognitive impairment.

     (2)Family Caregivers：

  1. Caregivers with severe organic lesions themselves;
  2. Caregivers who have experienced other major life events recently;
  3. Caregivers with a history of mental illness or severe cognitive impairment.