Comparison of Gingival Depigmentation Using Microneedling and Microneedling With Glutathione Gel - A Split Mouth Clinical Trial | NCT07748507

NCT07748507

Overview

NCT ID: NCT07748507
Lead Sponsor: Krishnadevaraya College of Dental Sciences & HospitalOTHER
Official Title: Comparison of Gingival Depigmentation Using Microneedling and Microneedling With Glutathione Gel - A Split Mouth Clinical Trial
Brief Summary: The colour of gingiva is important determinant of smile esthetics.Owing to increasing awareness and demand for cosmetic procedures over the past decade, gingival depigmentation has gained popularity among periodontal plastic surgical procedures.
Conditions: Gingiival Hyperpigmentation
Interventions: Microneedling using Dermapen device
Microneedling with 0.5 % Glutathione gel

Status and Timeline

Status: Completed
Last Update Posted: Aug 5, 2026Actual
Start Date: Jun 25, 2025Actual
Primary Completion Date: Dec 28, 2025Actual
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Patients between the age group of 18 to 45 years

Systemically healthy subjects

Maxillary or mandibular keratinised gingiva with minimum mean SEMPI score of 1(light grey / brown pigmentation) and above.

Exclusion Criteria:

Patients with thin gingival phenotype(<1mm)

Patients on drugs that cause oral pigmentation like antimalarials,minocycline, oral contraceptives etc.,

Systemic disorders that cause oral pigmentation ,Pregnant and lactating women

Subjects with history of smoking.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 15Actual
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking

Contacts and Locations

Central Contacts: No data available
Locations: krishnadevaraya college of dental sciences and Hospital

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