Retrospective Study of Romiplostim for Platelet Engraftment After Allo-HSCT | NCT07747246

NCT07747246

Overview

NCT ID: NCT07747246
Lead Sponsor: Tongji HospitalOTHER
Official Title: Retrospective Clinical Study on the Efficacy and Safety of Romiplostim for Promoting Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation
Brief Summary: This is a retrospective observational study evaluating the efficacy and safety of romiplostim for promoting platelet engraftment in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at Tongji Hospital Afﬁliated to Tongji Medical College of Huazhong University of Science and Technology between January 2025 to May 2026. Medical records were reviewed to collect data on platelet recovery time, transfusion requirements, and adverse events. The primary endpoint was time to platelet engraftment. Secondary endpoints included platelet recovery kinetics, transfusion requirements, transplant-related complications, and safety outcomes.No interventions were assigned as part of this study.
Conditions: Thrombocytopenia

Ages Eligible for Study: Child (0-17)Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Patients diagnosed with AA, AL, MDS, PMF, or other hematologic diseases according to internationally accepted diagnostic criteria

Patients who underwent allo-HSCT during the study period

Patients with complete clinical characteristics, transplantation records, and follow-up data

Exclusion Criteria:

Primary graft failure;

Death before hematopoietic engraftment

Missing key clinical data;(4) Use of thrombopoietin receptor agonists other than romiplostim

Central Contacts: No data available
Locations: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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