Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders | NCT07744490

NCT07744490

Overview

NCT ID: NCT07744490
Lead Sponsor: Shanghai Mental Health CenterOTHER
Official Title: A Longitudinal Study for Risk Identification of Common Mental Disorders in High-Risk Children and Adolescents
Brief Summary: This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and obsessive-compulsive disorder, based on family history or subthreshold emotional or behavioral symptoms. Participants will be followed for two years. Clinical assessments, questionnaires, EEG, biological samples, and MRI will be collected at scheduled intervals. The study aims to identify factors associated with the onset and progression of these disorders and support early risk identification.
Conditions: High Risk
Depression / Major Depressive Disorder
Anxiety Disease

Ages Eligible for Study: Child (0-17)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Aged 7-17 years at enrollment.

Meeting at least one of the following conditions: Having at least one first-degree relative with a depressive disorder, anxiety disorder, or obsessive-compulsive disorder; or exhibiting clinically relevant but subthreshold depressive, anxiety, obsessive-compulsive, or repetitive behavioral symptoms.

Not meeting the full diagnostic criteria for a depressive disorder, anxiety disorder, or obsessive-compulsive disorder at baseline, as assessed using the K-SADS-PL.

Willing and able to participate in the scheduled assessments and follow-up visits.

Written informed consent provided by a parent or legal guardian and assent provided by the participant

Exclusion Criteria:

A current or previous diagnosis of a depressive disorder, anxiety disorder, or obsessive-compulsive disorder.

A severe psychiatric condition requiring immediate clinical intervention, including acute suicide risk, a psychotic disorder, or a bipolar disorder.

A major neurological disorder, severe head injury, or serious or unstable medical condition that may interfere with study participation.

Intellectual or cognitive impairment that prevents the participant from understanding or completing the study assessments.

Inability or unwillingness of the participant or legal guardian to comply with the study procedures.

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