Bronchoscopy may cause coughing, discomfort, body movement, and changes in breathing or blood pressure. Propofol is commonly used for sedation during bronchoscopy, but it may cause respiratory depression, circulatory depression, and injection pain. Ciprofol is another intravenous sedative that may provide effective sedation with fewer adverse effects. This study compared ciprofol combined with low-dose sufentanil with propofol combined with low-dose sufentanil in adults undergoing bronchoscopy under intravenous sedation.
A total of 100 adults aged 35 to 65 years with no or mild systemic disease were randomly assigned in a 1:1 ratio to two treatment groups. Participants in one group received ciprofol and low-dose sufentanil, while participants in the other group received propofol and low-dose sufentanil. The study evaluated the amount of sedative used, adverse events, sedation onset time, recovery time, recovery quality, blood pressure, heart rate, oxygen saturation, and the overall effectiveness of anesthesia.
Inclusion Criteria:
Exclusion Criteria:
Participants were unaware of their assigned sedation regimen. Outcome assessors responsible for recording vital signs, recovery indicators, anesthesia effectiveness, and adverse events were separate from the anesthesiologists administering the study medications and remained unaware of group assignment throughout data collection. The anesthesiologists administering the study drugs were not masked because the two groups received different sedative drugs and doses.
Participants received sufentanil 0.1 micrograms/kg by slow intravenous injection over more than 30 seconds, followed by ciprofol 0.4 mg/kg by slow intravenous injection over more than 30 seconds. Bronchoscopy was initiated after disappearance of the eyelash reflex and achievement of a Modified Observer's Assessment of Alertness/Sedation score of 1 or lower. Standard physiological monitoring and supplemental oxygen were provided throughout the procedure.
Participants received sufentanil 0.1 micrograms/kg by slow intravenous injection over more than 30 seconds, followed by propofol 1.5 mg/kg by slow intravenous injection over more than 30 seconds. Bronchoscopy was initiated after disappearance of the eyelash reflex and achievement of a Modified Observer's Assessment of Alertness/Sedation score of 1 or lower. Standard physiological monitoring and supplemental oxygen were provided throughout the procedure.
Wenzhou, Zhejiang 325000, China
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