The goal of this clinical trial is to:
Inclusion Criteria:
Participant must self-identify as being of Middle Eastern or African descent.
Participant must be diagnosed with histologically or cytologically confirmed solid organ cancer and be treatment naive.
Participant must be between the ages of 18-80.
Participant or their legally authorized representative (LAR) must be able to understand a written informed consent document and be willing to sign it.
Exclusion Criteria:
Participants with active and uncontrolled bacterial, viral, or fungal infection requiring IV antibiotics.
• Participants may be eligible for the study if the infection is deemed to be under control per investigator's discretion.
Participants who have ever received cytotoxic chemotherapy.
• Those who have already started a chemotherapy regimen with moderate likelihood of developing neutropenia will be considered for enrollment at the principal investigator's discretion.
Participants who are receiving concurrent chemo-radiation treatment.
Participants who are taking any other investigational drugs.
Participants who are pregnant or breastfeeding.
Participants that do not agree to be followed according to the study protocol or have cognitive or physical inability to follow the treatment plan.
singhv@karmanos.org313-576-8381
In phase 2, Patients with a positive Duffy-null blood test plus standard of care chemotherapy with dose adjustment according to an algorithm created in phase 1 of this study.
In phase 2, patients with a negative Duffy-null blood test plus standard of care chemotherapy. Delays/modifications based on standard CTCAE (Common Terminology Criteria for Adverse Events) grading.
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