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NCT07742917

Overview

NCT ID: NCT07742917
Lead Sponsor: Institute for Healthier Living Abu DhabiOTHER
Official Title: Application of a Precision Lifestyle Medicine Clinical Program for a Sample of IFHAS Screening Cohort
Brief Summary: The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who have previously completed IFHAS screening. The study will also use IFHAS screening data to better understand participants' health profiles and the relationship between lifestyle factors and chronic diseases. The main questions it aims to answer are:

Does a precision lifestyle medicine program improve cardiometabolic biomarkers after an 18-week intervention?

Can IFHAS screening data be used to identify health risk profiles and support personalized lifestyle interventions for the Emirati population?

Researchers will compare participants receiving the precision lifestyle medicine intervention with a propensity-matched control group receiving standard IFHAS care to determine whether the intervention leads to greater improvements in cardiometabolic health.

Participants will:

Take part in an 18-week personalized lifestyle medicine program tailored to their health profile.

Attend study visits and complete health assessments over a total study period of 24 weeks.

Undergo cardiometabolic biomarker assessments before and after the intervention.

Complete questionnaires or assessments about their adherence to the lifestyle program and their experience with the precision lifestyle medicine clinic.

Provide biological samples to support the establishment of a biomarker repository for future research.

Status and Timeline

Status: Recruiting
Last Update Posted: Aug 3, 2026Actual
Start Date: Aug 3, 2026Estimated
Primary Completion Date: Jun 13, 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Emiratis residing in Abu Dhabi emirate

Aged 25-50 years

BMI 30-35 kg/m²

Thiqa cardholder

Previous participation in IFHAS screening

Able to provide informed consent

Participant in the Emirati Genome Programme

No weight-loss medications (e.g., Ozempic, Saxenda, Wegovy) within 3 months of enrollment.

Exclusion Criteria:

Aged under 25 years or over 50 years of age

BMI range under 30 kg/m2 and over 35 kg/m2

Taking weight loss medication such as GLP-1 drugs (Ozempic, Saxenda, Wegovy)

Active treatment for serious medical conditions (cancer, planned surgery, immunomodulation)

Transplant surgery within 12 months

Pregnancy

Surgery within 3 months prior to recruitment

Physical limitations preventing exercise participation

Current enrolment in other lifestyle intervention programs

Active psychiatric conditions, cognitive impairment, or mental health conditions affecting study participation

Contraindication to MRI or DEXA imaging, including severe claustrophobia or need for sedation.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 150Estimated
Primary Purpose: Treatment
Allocation: Non-Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Erik Koornneef, PhDContact
e.koornneef@ihlad.ae+971500888594

Similar Studies

Participant Group/Arms

Precision Lifestyle Medicine InterventionExperimental

Participants receive an 18-week precision lifestyle medicine intervention program based on IFHAS screening and risk stratification, including personalized lifestyle recommendations and clinical follow-up. Participants remain in the study for 24 weeks, with cardiometabolic outcomes assessed before and after the intervention.

Behavioral: Precision Lifestyle Medicine Program

Standard IFHAS Care (Matched Control)Active Comparator

Retrospective propensity score-matched control participants identified from the IFHAS cohort who receive standard IFHAS care and do not participate in the precision lifestyle medicine intervention. This comparison group is created using propensity score weighting to estimate intervention effects.

Other: Standard IFHAS Care