Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection | NCT07740382

NCT07740382

Overview

NCT ID: NCT07740382
Lead Sponsor: Menoufia UniversityOTHER
Official Title: Comparative Effects of Erector Spinae Plane Block and External Oblique Intercostal Plane Block on Postoperative Respiratory Recovery Following Liver Resection: A Randomized Controlled Trial
Brief Summary: This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.

The investigators hypothesize that bilateral ESP block improves postoperative respiratory function compared with EOIP block following open hepatic surgery. The investigators further hypothesize that this improvement is mediated, in part, by superior analgesia.
Conditions: Liver Resection
Upper Abdominal Surgeries

Status and Timeline

Status: Recruiting
Last Update Posted: Jul 31, 2026Actual
Start Date: Jul 1, 2026Estimated
Primary Completion Date: Jan 1, 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adult patients aged 18-75 years

Adult with American Society of Anesthesiologists (ASA) physical status I-III

Scheduled for elective hepatic surgery via upper abdominal incisions will be eligible.

All participants will be required to understand the Numeric Rating Scale (NRS) and provide informed consent.

Exclusion Criteria:

Patient refusal

Coagulopathy (INR>1.4 or platelet count<8 x 104)

Contraindications to fascial plane blocks

Infection at the puncture site

Known allergy to study medications

Chronic opioid use or chronic pain syndromes

Severe chronic respiratory failure requiring home oxygen or noninvasive ventilation

Pregnancy

Body mass index>40 kg/m²

When ultrasound imaging will be deemed unreliable

Emergency surgery

Hemodynamic instability

Reoperation during the same hospital admission.

Patients scheduled preoperatively for elective postoperative mechanical ventilation or planned ICU intubation.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 116Estimated
Primary Purpose: Diagnostic
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Contacts and Locations

Central Contacts: Nevine Mostafa SolimanContact
nevinemostafa@gmail.com01128861471

Similar Studies

Participant Group/Arms

The external oblique intercostal plane (EOIP) blockActive Comparator

newer fascial plane block that targets the thoracoabdominal nerves within the fascial plane between the external oblique and intercostal muscles. Its dermatomal coverage, typically spanning T6 to T10-T11, corresponds well with common upper abdominal surgical incisions. Emerging randomized data indicate that EOIP block provides effective postoperative analgesia and may be faster and technically easier to perform than deeper blocks. In open liver surgery, where subcostal and J-shaped incisions are frequently used, the EOIP block appears anatomically well-matched to the surgical field .

Procedure: Ultrasound-guided bilateral external oblique intercostal plane (EOIP) block

The erector spinae plane (ESP) blockActive Comparator

gained widespread use due to its relative technical simplicity, safety profile, and potential to provide both somatic and visceral analgesia. Meta-analytic evidence suggests that ESP block reduces postoperative opioid consumption and pain scores in abdominal surgery compared with control or alternative techniques.

Procedure: Ultrasound-guided bilateral erector spinae plane (ESP) block