Inclusion Criteria:

• Adult male or non-pregnant female volunteers (Age 18-79)
• Not currently taking more than two home oral antidiabetic agents, with or without a diagnosis of type 2 diabetes
• Able and willing to stop home oral antidiabetic medications for 5 days prior to the start of the study, with approval from healthcare providers
• Able and willing to give informed consent

Exclusion Criteria:

• Known contraindication for orforglipron (e.g., Personal or family history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia type 2 (MEN 2), allergies to any component)
• Personal history of pancreatitis, gallbladder disease, intestinal malabsorption, severe gastroparesis, gastric outlet obstruction, or other clinically significant gastrointestinal motility disorder
• History of liver disease or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >3 x upper limit of normal
• Estimated glomerular filtration rate (eGFR) < 45 mg/min/1.73m2 per the Modification of Diet in Renal Disease equation
• Active gallbladder disease or cholecystectomy within the past 6 months
• Current use of a strong CYP3A4 inducer (e.g., rifampin, carbamazepine, phenytoin, phenobarbital, rifabutin, or St. John's wort) or ritonavir, cobicistat, cyclosporine, or another strong CYP3A4 inhibitor that also inhibits OATP1B
• Current simvastatin dose >20 mg daily
• Measured most recent HbA1c level greater than 7.5% in the last 6 months
• Average glucose by fingerstick or continuous glucose monitor exceeding 180 mg/dL in the last 3 months
• Current uses of any oral or injectable GLP-1 receptor agonists, insulin, or the use of two or more antidiabetic agents
• Currently taking or planning to start other medication known to affect glycemic parameters, such as glucocorticoids, growth hormone, or fluoroquinolones during the study
• Planned to change any prescribed medication during the study
• Planned surgeries or procedures requiring general anesthesia during or within 10 days after completing the study
• Participating in any other interventional study simultaneously
• Dietary restrictions that prevent the consumption of the standardized liquid mixed meal
• Pregnant, nursing, or postpartum in the last 6 months
• Current suicidal ideation or suicide attempt within the past 5 years
• Psychiatric illness, substance use disorder, or eating disorder that, in the opinion of the investigator, would compromise participant safety or study compliance