Inclusion Criteria

• Adults diagnosed with Stage III or Stage IV periodontitis presenting with at least one mandibular molar with a Class II furcation defect requiring regenerative surgical treatment.
• Ability and willingness to provide written informed consent.
• Medically stable and able to undergo periodontal surgery.
• Willingness to comply with all study procedures and follow-up visits.

Exclusion Criteria

• Stage I or Stage II periodontitis.
• Current smokers.
• Uncontrolled diabetes mellitus.
• Alcohol or substance use disorder.
• Chronic inflammatory diseases requiring continuous anti-inflammatory therapy.
• Current use of bisphosphonates or other medications associated with medication-related osteonecrosis of the jaw.
• Current use of medications known to induce gingival enlargement.
• Continuous use of systemic antibiotics or anti-inflammatory medications.
• Pregnant or breastfeeding individuals.
• Known allergy or hypersensitivity to the antibiotics, local anesthetics, or other study-related medications.
• Medical conditions that, in the investigator's judgment, make the participant unsuitable for periodontal surgery or study participation.