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NCT07738133

Overview

NCT ID: NCT07738133
Lead Sponsor: Medical College of WisconsinOTHER
Official Title: Probing Brain Network Mechanisms Underlying Late-Life Prolonged Grief Disorder
Brief Summary: After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues. This study is anticipated to provide novel evidence regarding the neurobiological mechanisms of PGD in older adults. The biological alterations identified here could provide targets to elucidate how currently available therapies work and inform novel mechanism-based interventions for treating late-life PGD.
Conditions: Prolonged Grief Disorder
Interventions

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Male or female greater than or equal to 40 years of age

Bereavement >6 months

Score greater than or equal to 25 on the Inventory of Complicated Grief (ICG)

Presence of PGD (subsyndromal and syndromal)

Adequate visual and auditory acuity

Exclusion Criteria:

Delirium/unstable medical conditions

Lifetime history of neurological illnesses: seizures, stroke, dementia of any -etiology, severe head injury, brain tumor or surgery

Serious back, joint or neck injuries within the past 3 months

Currently practicing yoga

Gross structural abnormalities on T1-weighted images

Lifetime history of the following psychiatric disorders: bipolar or psychotic -disorders, including psychotic depression

Current alcohol/drug abuse or dependence

Magnetic resonance imaging (MRI) contraindications

Acute suicidality