2D:4D Digit Ratio and Urinary Stone Disease | NCT07736924

NCT07736924

Overview

NCT ID: NCT07736924
Lead Sponsor: Emrah KızılayOTHER
Official Title: Association Between 2D:4D Digit Ratio and Urinary Stone Disease: A Prospective Observational Case-Control Study
Brief Summary: This prospective observational case-control study will investigate whether the 2D:4D digit ratio is associated with urinary stone disease. Adults undergoing non-contrast computed tomography at Malatya Training and Research Hospital will be classified as cases if kidney and/or ureteral stones are detected and as controls if no urinary stones are detected and there is no previous history of stone disease or stone surgery. The lengths of the second and fourth fingers of both hands will be measured using a digital caliper by two independent observers who are blinded to the participant group. The study will also examine whether the 2D:4D ratio is associated with recurrent stone disease, stone burden, and bilateral or multiple stones.
Conditions: Urinary Stone

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Age 18 years or older

Provision of written informed consent

Undergoing non-contrast computed tomography at Malatya Training and Research Hospital during the study period

For cases: presence of at least one kidney and/or ureteral stone on non-contrast computed tomography

For controls: absence of stones in the kidneys, ureters, and bladder on non-contrast computed tomography

For controls: no previous physician-diagnosed urinary stone disease or history of stone-related surgery

Feasibility of bilateral second- and fourth-digit length measurements

Exclusion Criteria:

Congenital deformity of the hands or fingers

History of hand or finger trauma, fracture, surgery, or amputation that may affect digit length measurement

Severe hand deformity, contracture, or advanced joint disease preventing reliable measurement

Incomplete, inadequate, or technically unreliable 2D:4D measurements

Missing essential clinical, demographic, or imaging data

Pregnancy

Presence of bladder stones

Urinary diversion, major urinary tract reconstruction, or a significant structural urinary tract anomaly

Central Contacts: Emrah KIZILAY, MDContact
emrahkizilay@hotmail.com+905363887322