This study is a real-world, prospective clinical cohort study. It will enroll Chinese patients with type 2 diabetes. The aim is to assess the changes in aging biomarkers, primarily DunedinPACE, from baseline to post-remission, and to compare these biomarkers between patients who achieve successful remission and those who do not.
Inclusion Criteria:
Exclusion Criteria:
Diabetes mellitus secondary to other causes (e.g., Cushing's syndrome, hypothyroidism, glucagonoma, drug-induced, or genetic factors).
BMI <25 kg/m² or >45 kg/m²; weight loss >5% within the last 3 months; actively trying to lose weight within the last 3 months; use of weight-loss agents, contraceptives, glucocorticoids, or any medication other than antidiabetic drugs that may affect study outcome measurements within the last 3 months; history of bariatric surgery.
Type 1 diabetes; type 2 diabetes duration >10 years; gestational diabetes; other specific types of diabetes.
Diagnosis of acute metabolic diabetic complications (e.g., diabetic ketoacidosis or hyperosmolar hyperglycemic state) or diabetes insipidus within 30 days, or history thereof.
Blood pressure ≥180/110 mmHg or malignant hypertension.
History of severe gastrointestinal disease; significant cardiac, hepatic, renal, or other systemic organ dysfunction (NYHA functional class ≥II; ALT and/or AST >4× upper limit of normal; GFR <60 mL/min); anemia or other hematological disorders; history of malignancy.
History of bariatric surgery or other gastrointestinal surgery causing chronic malabsorption within the past 2 years.
Use within 3 months prior to screening of any of the following:
i. GLP-1 receptor agonists, GLP-1R/GCGR agonists, GIPR/GLP-1R agonists, or GIPR/GLP-1R/GCGR agonists; ii. Medications affecting body weight, including systemic corticosteroids (intravenous, oral, or intra-articular), tricyclic antidepressants, psychiatric medications, or sedatives (e.g., imipramine, amitriptyline, mirtazapine, paroxetine, phenelzine, chlorpromazine, thioridazine, clozapine, olanzapine, valproic acid, valproate derivatives, lithium); iii. Chinese herbal medicines, dietary supplements, or meal replacements that affect body weight; iv. Previous or current use of anti-obesity drugs such as sibutramine, orlistat, phentermine, phenylpropanolamine, mazindol, diethylpropion, lorcaserin, phentermine/topiramate, naltrexone/bupropion; consumption of any alcoholic product within 48 hours prior to screening, or a positive alcohol screening test.
Drug abuse or alcohol dependence; severe psychiatric or neurological disorders.
Pregnant or breastfeeding women, or women planning to become pregnant within 1 year.
Special dietary requirements, or allergy to soy, dairy, or other foods.
Current participation in another clinical trial; unwillingness to comply with the lifestyle management and follow-up of this study; or judged by the investigator to be unsuitable for participation.
Unwilling or unable to provide informed consent.
pengfeishan@zju.edu.cn86-0571-87783777
Type 2 Diabetes Remission
Digital, Blended Lifestyle Intervention for Type 2 Diabetes Remission
Remission of Type 2 Diabetes With Dapagliflozin (READ Trial)
The Influence of Partial Remission Phase of Type 1 Diabetes on Patient Outcome
REMEDIES4D: REdesigning MEDication Intensification Effectiveness Study for Diabetes
Diabetes Type 1 and Fitness.
Lifestyle Intervention for Senior Diabetics
Fasting-Associated Immune-metabolic Remission of Diabetes