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NCT07735442

Overview

NCT ID: NCT07735442
Lead Sponsor: Dana-Farber Cancer InstituteOTHER
Official Title: Better Real-time Information on Documentation of Goals of Care for Engagement in Serious Illness Communication (BRIDGE-SIC)
Brief Summary: This is a pragmatic, prospective, randomized clinical trial to test the effectiveness of large language model (LLM)-generated serious illness conversation (SIC) summaries delivered to patients' inpatient and outpatient clinicians at the time of hospital admission on the primary outcome of days in the hospital in the next 90 days.
Conditions: Cancer
Interventions: LLM-generated SIC summary email to clinical teams

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 30, 2026Actual
Start Date: Jul 31, 2026Estimated
Primary Completion Date: Jun 30, 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

DFCI Patients, defined as patients who have a DFCI medical record number.

Admitted to an inpatient solid tumor medical oncology service at BWH (including beds that are considered to be DFCI beds within BWH)

Age ≥ 18 years

Mortality prediction ≥ 25%

Admitted on a Sunday after 4pm through Friday at 4pm. These time restrictions are necessary for the workflow of this pragmatic pilot trial, as the intervention requires a staff member to send intervention emails during the work week but within <= approximately 18 hours of admission. Accordingly, we will not enroll patients during holiday time periods (e.g., for a Monday holiday, enrollment would start on Monday at 4pm instead of Sunday at 4pm) or on days where staff absences (e.g., illness) preclude enrollment.

Exclusion Criteria:

• Patients with elective inpatient admissions (typically for planned administration of chemotherapy or other treatments)

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 600Estimated
Primary Purpose: Other
Allocation: Randomized
Interventional Model: Single Group Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Alexi A Wright, MD, MPHContact
alexi_wright@dfci.harvard.edu6176322334

Similar Studies

Participant Group/Arms

Arm 1: Intervention ArmOther

Patients receive an email sent to their inpatient and outpatient clinical teams containing an LLM-generated summary of prior SIC documentation, prompting clinicians to review and discuss care preferences with the patient and align care with patient goals.

Behavioral: LLM-generated SIC summary email to clinical teams

Arm 2: Control ArmNo Intervention

Patients receive standard of care; SICs may be initiated by patients or clinicians as usual.

Locations

Brigham and Women's Hospital

Boston, Massachusetts 02214, United States

Alexi A Wright, MD.MPHContact

alexi_wright@dfci.harvard.edu617-632-2334

Charlotta J Lindvall, MD PhDContact

charlotta_lindvall@dfci.harvard.edu6175823401

Alexi A Wright, MD, MPHPrincipal Investigator

Charlotta J Lindvall, MD PhDPrincipal Investigator

Dana Farber Cancer Institute

Boston, Massachusetts 02215, United States