This prospective study evaluates whether a more detailed clinical and genetic assessment can improve the classification of individual breast cancer risk among women previously identified as having moderately increased or high breast cancer risk in the Slovenian DORA breast cancer screening programme.
Women who agree to participate complete questionnaires and attend an individual genetic counseling appointment at the Institute of Oncology Ljubljana. Personal breast cancer risk factors are reviewed with the assistance of a specialist, and reported family cancer history is verified using data from the Slovenian Cancer Registry. Breast cancer risk is reassessed using the S-IBIS and CanRisk models. Genetic testing is offered to participants who meet the applicable clinical criteria.
The study will evaluate changes in breast cancer risk classification, compare risk estimates obtained using the S-IBIS and CanRisk models, and provide participants with individualized recommendations for breast cancer screening and follow-up according to their reassessed risk.
Inclusion Criteria:
- Women who participated in the previous DORA study and were classified by the S-IBIS model as having moderately increased or high breast cancer risk.
Exclusion Criteria:
genetika@onko-i.si+386 1 587 9649
Participants undergo a comprehensive reassessment of individual breast cancer risk. The assessment includes specialist-assisted review of personal risk factors, verification of family cancer history, risk calculation using the S-IBIS and CanRisk models, genetic counseling, and genetic testing when clinically indicated. Participants receive risk-adapted recommendations for further breast cancer screening and follow-up.
Decision Support for BRCA Testing in Ethnically Diverse Women
Breast Cancer Risk After Diagnostic Gene Sequencing
Comprehensive Genetic Assessment, Risk and Education in a Mammography Pilot
Risk Education and Assessment for Cancer Heredity
Genetic Counseling in Women at Risk for BRCA1 or BRCA2 Mutations
Genetic Education in BRCA Families
Personalized Breast Cancer Screening
Personalised Risk-based Breast Cancer Prevention and Screening