The goal of this clinical trial is to investigate how semaglutide affects the way the brain responds to food in adults with obesity and food addiction tendencies.
The main goals of this study are:
Adults with obesity and food addiction tendencies will join this study. Each participant will receive semaglutide treatment for 8 weeks. Each participant will have two brain scans using [11C]raclopride PET.
During each PET scan, participants will:
Inclusion Criteria:
Exclusion Criteria:
nova2123@snu.ac.kr+821097262123
Participants undergo a baseline \[11C\]raclopride PET scan before semaglutide treatment. They then receive an 8-week semaglutide dose-escalation treatment, followed by a second \[¹¹C\]raclopride PET scan at the end of treatment.
Participants first receive an 8-week semaglutide dose-escalation treatment and undergo a \[¹¹C\]raclopride PET scan at the end of treatment. After an 8-week washout period, they undergo a second \[¹¹C\]raclopride PET scan.
Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects
A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity
The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients
Trial Investigating the Effect of Semaglutide on Energy Intake, Appetite Sensations, Postprandial Glucose and Triglyceride Metabolism and Gastric Emptying in Obese Subjects Compared With Placebo
GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight
Semaglutide and Cognition in Healthy Volunteers
Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss
A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensations and Gastric Emptying in Subjects With Type 2 Diabetes