This single-centre, prospective, controlled, non-interventional observational clinical study aims to characterize early postoperative corneal thickness behaviour after routine phacoemulsification cataract surgery in eyes with Fuchs endothelial corneal dystrophy (FECD) compared with non-FECD controls, using exclusively standard-of-care perioperative assessments. To compare central corneal thickness (CCT) six weeks postoperatively between FECD and non-FECD eyes, adjusting for baseline (preoperative) CCT.
All participants undergo routine phacoemulsification cataract surgery and routine perioperative assessments. Data are collected from the standard-of-care documentation at the following time points:
The routine clinical parameters assessed (as available per standard practice) include:
Inclusion Criteria:
Signed written informed consent for participation and for use of routine clinical data in pseudonymised form.
Age ≥50 years at the time of cataract surgery.
Scheduled cataract surgery (unilateral/bilateral cataract).
No evidence of other ophthalmic diseases (e.g. macular pathology)
Cohort-specific inclusion:
FECD cohort: Clinical diagnosis of FECD based on slit-lamp findings, graded accord-ing to Krachmer et al. (1978) as documented in routine care.
Control cohort: No clinical evidence of corneal endothelial disease at baseline (no signs consistent with FECD or other endothelial pathology) as documented in routine care.
Exclusion Criteria:
Patients with FECD
Patients without FECD
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