Inclusion Criteria:

• Age 40-80
• Willing and able to attend all study visits, comply with study requirements.
• Able and willing to provide written informed consent
• Documented COPD diagnosis prior for at least 12 months prior to screening.
• Currently receiving maintenance COPD medications at a stable dose for at least 2 months prior to visit 1

Exclusion Criteria:

• Evidence of clinically significant pulmonary condition or disease other than COPD
• Any physical or psychological condition that prohibits study completion
• Known history of illicit drug use or drug abuse, harmful alcohol use (at the Investigator's discretion), alcoholism within 12 months prior to the first dose of study agent
• History of severe allergic reactions or hypersensitivity
• Receipt of immunosuppressant therapies for asthma within 3 months of screening
• Major surgery occurring within 8 weeks months prior to first dose of investigational product.
• Use of any marketed or investigational monoclonal or polyclonal antibody therapy within 4 months or 5 half-lives prior to visit 1.